An Asymptotic Analysis of the Mean First Passage Time for Narrow Escape Problems: Part II: The Sphere

نویسندگان

  • Alexei F. Cheviakov
  • Michael J. Ward
  • Ronny Straube
چکیده

The mean first passage time (MFPT) is calculated for a Brownian particle in a spherical domain in R that contains N small non-overlapping absorbing windows, or traps, on its boundary. For the unit sphere, the method of matched asymptotic expansions is used to derive an explicit three-term asymptotic expansion for the MFPT for the case of N small locally circular absorbing windows. The third term in this expansion, not previously calculated, depends explicitly on the spatial configuration of the absorbing windows on the boundary of the sphere. The three-term asymptotic expansion for the average MFPT is shown to be in very close agreement with full numerical results. The average MFPT is shown to be minimized for trap configurations that minimize a certain discrete variational problem. This variational problem is closely related to the well-known optimization problem of determining the minimum energy configuration for N repelling point charges on the unit sphere. Numerical results, based on global optimization methods, are given for both the optimum discrete energy and the arrangements of the centers {x1, . . . , xN} of N circular traps on the boundary of the sphere. A scaling law for the optimum discrete energy, valid for N 1, is also derived.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

An Asymptotic Analysis of the Mean First Passage Time for Narrow Escape Problems

The mean first passage time (MFPT) is calculated for a Brownian particle in a bounded twoor three-dimensional domain that contains N small non-overlapping absorbing windows on its boundary. The reciprocal of the MFPT of such narrow escape problems has wide applications in cellular biology where it may be used as an effective first order rate constant to describe, for example, the nuclear export...

متن کامل

Mathematical modeling and numerical computation of narrow escape problems.

The narrow escape problem refers to the problem of calculating the mean first passage time (MFPT) needed for an average Brownian particle to leave a domain with an insulating boundary containing N small well-separated absorbing windows, or traps. This mean first passage time satisfies the Poisson partial differential equation subject to a mixed Dirichlet-Neumann boundary condition on the domain...

متن کامل

An Asymptotic Analysis of the Mean First Passage Time for Narrow Escape Problems: Part I: Two-Dimensional Domains

The mean first passage time (MFPT) is calculated for a Brownian particle in a bounded two-dimensional domain that contains N small non-overlapping absorbing windows on its boundary. The reciprocal of the MFPT of this narrow escape problem has wide applications in cellular biology where it may be used as an effective first order rate constant to describe, for example, the nuclear export of messe...

متن کامل

Asymptotic analysis of narrow escape problems in nonspherical three-dimensional domains.

Narrow escape problems consider the calculation of the mean first passage time (MFPT) for a particle undergoing Brownian motion in a domain with a boundary that is everywhere reflecting except for at finitely many small holes. Asymptotic methods for solving these problems involve finding approximations for the MFPT and average MFPT that increase in accuracy with decreasing hole sizes. While rel...

متن کامل

Narrow Escape, Part II: The Circular Disk

We consider Brownian motion in a circular disk , whose boundary ∂ is reflecting, except for a small arc, ∂ a , which is absorbing. As ε = |∂ a |/|∂ | decreases to zero the mean time to absorption in ∂ a , denoted Eτ , becomes infinite. The narrow escape problem is to find an asymptotic expansion of Eτ for ε 1. We find the first two terms in the expansion and an estimate of the error. The result...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Multiscale Modeling & Simulation

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2010